Module

Genetics and Molecular Pathogenesis of Melanoma: Current Understanding

Source: Melanoma Treatment Update

Genetics and Molecular Pathogenesis of Melanoma: Current Understanding

Faculty:

Hensin Tsao, MD, PhD

CME CREDIT INFORMATION

Release Date: 03/03/08

Expiration Date: 03/02/09

Physicians: maximum of 1.0 AMA PRA Category 1 Credit™

Registered Nurses: 1.0 Nursing CE credit

Status: Please log in to view status

Learning Objectives

Upon completion of this activity, participants should be able to:

Identify inherited genetic factors that increase an individual’s risk of developing melanoma
Summarize current hypotheses and supporting data relating to disruptions of key signaling pathways in melanoma
Review the role of immune surveillance defects in melanoma oncogenesis
Discuss possible future implications of progress in understanding melanoma pathogenesis for prognosis and treatment

Topics covered include:

Introduction
Genetic Predisposition to Melanoma
Sunlight in Melanoma: An Uncertain Role
The RAS Signaling Network and Melanoma Pathogenesis: The RAS/MAPK Pathway
The RAS Signaling Network and Melanoma Pathogenesis: The RAS/PI3K Pathway
Melanocyte Development Genes: KIT and MITF
Tumor Factors and Immune Escape
Emerging Implications for Diagnosis, Prognosis, and Therapy

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