
Elias Jabbour, MD; Jorge E. Cortes, MD; and Hagop M. Kantarjian, MD, discuss current and evolving treatments for chronic myeloid leukemia.
Learning Objectives
Upon completion of this activity, participants should be able to:
- Discuss the pathophysiology of Philadelphia-chromosome positive CML, including the mechanisms by which resistance to standard therapy can emerge
- Describe the activity of tyrosine kinase inhibitors and the rationale for their use in CML
- Articulate current clinical data on the efficacy of newer oral therapies in the treatment of imatinib-resistant CML