Module

The Role of Predictive Factors in Guiding Treatment Decisions for Estrogen Receptor–Positive Postmenopausal Breast Cancer

Source: Management of ER+ Postmenopausal Early Breast Cancer

The Role of Predictive Factors in Guiding Treatment Decisions for Estrogen Receptor–Positive Postmenopausal Breast Cancer

Program Director: Paul E. Goss, MD, PhD, FRCPC, FRCP

Faculty:

William J. Gradishar, MD, FACP

CME CREDIT INFORMATION

Release Date: 05/28/08

Expiration Date: 05/27/09

Physicians: maximum of 1.0 AMA PRA Category 1 Credit™

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Learning Objectives

Upon completion of this activity, participants should be able to:

Describe the role of genetic profiling tests in the selection of optimal treatment approaches for patients with early-stage hormone receptor–positive breast cancer
Discuss how to estimate the benefits of endocrine therapy in various populations of breast cancer patients
Cite recent clinical trial data from studies of chemotherapy combinations in the settings of node-positive and node-negative breast cancer

Topics covered include:

Introduction
Estimating Benefit From Endocrine Therapy
Adjuvant! Online in Estimating Risk
Genetic Profiling
Validation of the 21-Gene RS Assay
NSABP B-20 Trial
ECOG 2197 Study: Evaluation of RS in Node-Positive Disease
SWOG 8814 Trial: Evaluation of RS in Lymph-Node-Positive Disease
Prognostic Utility of the 70-Gene Assay
TAILORx and MINDACT Trials
Conclusion

Disclaimer: The materials published on the Clinical Care Options Web site reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the CME provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.