Learning Objectives
Upon completion of this activity, participants should be able to:
- Specify standard definitions of response and nonresponse to hepatitis C virus therapy
- Discuss factors associated with nonresponse to hepatitis C virus therapy
- Report criteria that may help to identify nonresponders who are good candidates for retreatment
- Summarize data from studies of different retreatment strategies
- Describe appropriate virologic goals of therapy for nonresponders undergoing retreatment
Topics covered include:
- Introduction
- Defining the Patterns of Virologic Response and Nonresponse
- Rapid Virologic Response
- Achieving Undetectable HCV RNA After Week 4 and Slow Virologic Response
- Early Virologic Response and Nonresponse Virologic Patterns
- Breakthrough and Relapse
- Identifying Candidates for Retreatment: Null Response
- Identifying Candidates for Retreatment: Partial Virologic Response
- Identifying Candidates for Retreatment: Noncompliance, Medication Errors and Dose Reduction
- Identifying Candidates for Retreatment: Failure to Recognize That Virologic Response Has Occurred
- Identifying Candidates for Retreatment: Insufficient Treatment Duration
- Conclusions
- Summary of Clinical Implications