Implications of New Data on Complications Associated With ARV Regimens
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Pablo Tebas, MD, discusses implications of recent data suggesting that certain antiretroviral agents are associated with loss in bone mineral density and renal disease.
Format: Microsoft PowerPoint (.ppt) |
File size: 414 KB
| Date posted: 6/22/2010
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Neurocognitive Dysfunction in HIV-Infected Patients
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Scott L. Letendre, MD, discusses possible causes and implications of neurocognitive disease in HIV-infected patients.
Format: Microsoft PowerPoint (.ppt) |
File size: 307 KB
| Date posted: 6/22/2010
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Tenofovir-Associated Renal Dysfunction Improved but Not Fully Reversible Following Tenofovir Cessation in Majority of Patients
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Pre-tenofovir eGFR restored in only 42% of patients following tenofovir cessation; of these, only 2 patients no longer met the definition of renal impairment.
Format: Microsoft PowerPoint (.ppt) |
File size: 285 KB
| Date posted: 6/21/2010
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Neurocognitive Function Improves With Initial Antiretroviral Therapy; Differences Between Regimens Noted
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Greatest improvement in neurocognitive function seen with all-NRTI regimen but greatest neuronal recovery seen with efavirenz-based regimen.
Format: Microsoft PowerPoint (.ppt) |
File size: 260 KB
| Date posted: 6/18/2010
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Integrase Resistance Evolves Progressively During Failure of Integrase Inhibitor–Based Antiretroviral Therapy
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In an analysis of the SCOPE cohort, first virologic failure of an integrase inhibitor in treatment-experienced patients was associated with resistance mutations present in only a minority of patients but evolution and accumulation of resistance with longer time on failing integrase inhibitor regimen.
Format: Microsoft PowerPoint (.ppt) |
File size: 255 KB
| Date posted: 6/16/2010
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Fewer Deaths With Concurrent vs Sequential Antiretroviral and TB Therapy
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In the SAPIT trial, initiation of antiretroviral therapy during TB therapy associated with 56% reduction in risk of death vs initiating antiretroviral therapy following TB therapy completion
Format: Microsoft PowerPoint (.ppt) |
File size: 402 KB
| Date posted: 6/15/2010
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Acyclovir Reduces Risk of HIV Disease Progression in HIV/HSV-2–Coinfected Patients Not Receiving Antiretroviral Therapy
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But, suppression of HSV-2 by acyclovir did not reduce HIV-1 transmission.
Format: Microsoft PowerPoint (.ppt) |
File size: 353 KB
| Date posted: 6/15/2010
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Maraviroc Plus Zidovudine/Lamivudine Noninferior to Efavirenz Plus Zidovudine/Lamivudine as Initial ART in Patients With CCR5-Tropic HIV Only by Sensitive Phenotypic Tropism Assay
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In post hoc reanalysis of trial samples with highly sensitive phenotypic tropism assay, eliminating additional patients with CXCR4-using variants at baseline, maraviroc-containing regimen met noninferiority criteria; virologic responses similar to efavirenz-containing regimen at Week 48.
Format: Microsoft PowerPoint (.ppt) |
File size: 542 KB
| Date posted: 6/15/2010
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SWITCHMRK: Switch to Raltegravir-Based Regimen Virologically Inferior to Continuing Lopinavir/Ritonavir-Based Regimen in Patients With Stable Viral Suppression
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Lopinavir/ritonavir-based regimen associated with higher proportion of patients with HIV-1 RNA < 50 copies/mL at Week 24 in a diverse study population that included some patients with extensive treatment experience.
Format: Microsoft PowerPoint (.ppt) |
File size: 644 KB
| Date posted: 6/15/2010
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Severe Vitamin D Deficiency in Swiss HIV-Infected Patients Not Associated With Antiretroviral Therapy
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Retrospective analysis shows substantially higher rates of vitamin D deficiency in HIV-infected Swiss patients in spring vs fall; multiple demographic and treatment factors significantly correlated with vitamin D levels in multivariate analysis.
Format: Microsoft PowerPoint (.ppt) |
File size: 406 KB
| Date posted: 6/15/2010
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Building a Bridge to Better HIV Care
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Kathleen E. Squires, MD, Alice C. Thornton MD, AAHIVS, and expert faculty review steps appropriate for management of the HIV-infected patient at various points in the treatment spectrum in this practical, guidelines-supported slideset.
Format: Microsoft PowerPoint (.ppt) |
File size: 802 KB
| Date posted: 6/10/2010
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