Conference Track

Pharmacology & Adverse Events

Source: CCO Independent Conference Coverage of the 2005 International AIDS Society Conference on HIV Pathogenesis and Treatment*

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

Capsule Summaries

Lopinavir/Ritonavir-Based Regimen Produces Rapid Viral Load Decrease in Young Children Despite Low Plasma Drug Concentrations
Variable Plasma Drug Levels in Children Receiving Lopinavir/Ritonavir
HIV-1 Disease, Not HAART Use, Linked to Bone Demineralization
Elevated Incidence of Thyroid Disease Among Patients on HAART
Mitochondrial Toxicity Associated With Concurrent Tenofovir/Didanosine Treatment May Contribute to Renal Dysfunction
Significantly Increased Exposure to Coreceptor Antagonist Vicriviroc (SCH-417690) When Coadministered With Ritonavir
Ritonavir and/or Triple-NRTI Therapy Associated With Increased Risk of Renal Insufficiency in Tenofovir Recipients
Select Laboratory Adverse Events Related to Antiretroviral Therapy Predict Mortality
Novel Lopinavir/Ritonavir Formulation Decreases Variability in Drug Levels, Pill Burden
Adverse Effects Limit Usefulness of Combining Rifampin-Based Tuberculosis Regimens with Ritonavir/Saquinavir-Based Antiretroviral Therapy
Once-Daily Dosing of Lopinavir/Ritonavir Coformulation as Effective as Twice-Daily Dosing, But With Increased Diarrhea
No Observed Increase in Complications in South African Patients Initiating Nevirapine-Based HAART With Concomitant Rifampin

Expert Analysis

Pharmacology and Adverse Events

Program Director: John P. Phair, MD

Faculty:

Terrence F. Blaschke, MD
Courtney V. Fletcher, PharmD
William G. Powderly, MD

Learning Objectives

Upon completion of this activity, participants should be able to:

Describe recent data on drug-drug interactions between antiretroviral agents.
Review data on adverse effects associated with the use of Highly Active Antiretroviral Therapy (HAART).
Discuss novel dosing regimens for administration of lopinavir/ritonavir in adults and children.

CME CREDIT INFORMATION

Release Date: 09/23/05

Expiration Date: 09/22/06

Physicians: maximum of 1.25 AMA PRA Category 1 Credits™

Registered Nurses: 1.6 Nursing CE credits

Pharmacists: 1.4 contact hours (0.14 CEUs)

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