Expert Analysis

Antiretroviral Drug Resistance

Source: CCO Independent Conference Coverage of the 2008 Conference on Retroviruses and Opportunistic Infections*

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

Antiretroviral Drug Resistance

Faculty:
Eric S. Daar, MD Daniel R. Kuritzkes, MD Andrew R. Zolopa, MD

CME CREDIT INFORMATION

Release Date: 03/28/08

Expiration Date: 03/27/09

Physicians: maximum of 1.25 AMA PRA Category 1 Credit(s)™

Pharmacists: 1.3 contact hours (0.13 CEUs)

Registered Nurses: 1.3 Nursing CE credits

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Learning Objectives

Upon completion of this activity, participants should be able to:

Describe new data on strategies to reduce drug resistance associated with antiretroviral therapy for prevention of mother-to-child HIV transmission
Discuss recent findings on the impact of minority variants on virologic response to NNRTI-based regimens
Summarize new data on novel approaches to evaluate viral tropism
Cite recent insights into resistance from studies of maraviroc, darunavir/ritonavir, lopinavir/ritonavir, and etravirine

Topics covered include:

Strategies to Reduce Drug Resistance Associated With Use of Antiretroviral Therapy to Prevent MTCT
ACTG A5146: PI Dose Adjustment for Patients With a Low Pharmacologic Inhibitory Quotient
ACTG 5077: Comparison of HIV Sequences in Plasma and Genital Compartments
Impact of Minority NNRTI-Resistant Variants on Virologic Response to NNRTI-Based Therapy
Novel Approaches to Evaluate HIV-1 Chemokine Coreceptor Tropism
Causes of Failure and Resistance in MERIT and MOTIVATE
TITAN: Resistance Following Failure of Darunavir/Ritonavir vs Lopinavir/Ritonavir in Treatment-Experienced Patients
Virtual Phenotype Clinical Cutoffs for Etravirine Susceptibility

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