Interactive Case Challenges

The Role of Integrase Inhibitors in HIV Management

• Management of a Virologically Suppressed Patient Experiencing Injection Site Reactions With His Current Regimen
• Management of a Patient With Extensive Antiretroviral Experience and Persistent Low-Level Viremia

Psychiatric Disorders in HIV-Infected Patients

• Initiating Therapy in a Patient With Substance Abuse Disorder
• Managing Therapy in a Patient With Increasing Anxiety
• Managing Adherence in a Patient With Multiple Medical Disorders and an Affective Disorder

When to Start, What to Use: A Master Class in the Use of First-Line Antiretroviral Therapy

• When to Initiate Therapy in a Patient Recently Diagnosed With HIV
• Management of an HIV-Infected Treatment-Naive Diabetic Female With Dyslipidemia
• Treatment Considerations in an HIV-Infected Patient With Ongoing Methamphetamine Use

Simple From the Start: The Importance of Treatment Convenience in Antiretroviral Therapy

• Selection of Initial Therapy for a 48-Year-Old HIV/TB-Coinfected Woman With Cardiovascular Disease Risk Factors
• Management of a 38-Year-Old Male on Methadone Maintenance Therapy Who Presents With PCP
• Management of a 38-Year-Old Otherwise Healthy Married Man Recently Diagnosed With HIV Infection

Managing Cardiovascular Risk in HIV-Infected Patients: The Role of Antiretroviral Selection

• Selection of an Initial Regimen for a Patient With a Family History of Cardiovascular Disease
• Management of Dyslipidemia in an HIV-Infected Man With Grave Cardiac Risk

From Theory to Practice: Strategies for the Successful Management of Treatment-Experienced Patients

• Management of a Moderately Treatment–Experienced HIV-Infected Patient With Virologic Failure
• Management of a Highly Treatment-Experienced HIV-Infected Patient With Low-Level Viremia and a High CD4+ Cell Count
• Practical Strategies for Managing Treatment-Experienced Patients: An Overview of the Wave 1 Interactive Case Challenges

Dyslipidemia and Other Cardiovascular Risk Factors in HIV: Causes, Clinical Significance, and Management Strategies

• HAART Initiation in an Overweight Female With Advanced HIV Disease
• Management of a 45-Year-Old, HIV-Infected Man With Dyslipidemia While on HAART
• Management of Dyslipidemia in a 55-Year-Old Man at Very High Cardiovascular Risk

NNRTIs in Clinical Practice: An Update

• Management of Adverse Effects in a Woman Switching From Fixed-Dose NRTIs to a DHHS-Recommended Regimen
• Treatment of a Newly Diagnosed HIV-Infected 24-Year-Old Male With Suboptimal Adherence

Choosing an Initial Protease Inhibitor for PI-Naive Patients

• Management of an HIV-infected, Treatment-Naive, Vietnam War Veteran With a History of Poorly Controlled Paranoid Schizophrenia
• Management of a Patient With Virologic Failure on His Initial NNRTI-Based Triple-Therapy
• Choice of an Initial PI for a Patient With Hypertension and NNRTI Resistance

Recent Advances in Managing Neurologic Adverse Effects of Antiretroviral Therapy

• An HIV-Infected Man Who Presents With Sensory Disturbances
• Clinical Management of an HIV-Positive Man Experiencing Dizziness, Vivid Dreams, and Anxiety

Fine-Tuning Antiretroviral Therapy in HIV-Infected Patients With Virologic Suppression: Strategies to Address Toxicity, Convenience, and Quality of Life

A series of 3 interactive case challenges designed to explore clinical decision making regarding modification of antiretroviral therapy in patients with virologic suppression.

• Management of a Virologically Suppressed Patient Experiencing Difficulty Adhering to His Initial NNRTI-Based Regimen
• A 36-Year-Old Male Patient With Virologic Suppression Experiencing Progressive Lipoatrophy
• A 48-Year-Old HIV-Infected Man With Hyperlipidemia on HAART

Neurologic Aspects of HIV/AIDS: New Insights and Management Advances

• An HIV-Infected Man Who Presents With Subacute Neurologic Symptoms
• A Man With Advanced AIDS With an Episode of Loss of Consciousness
• An HIV-Infected Man Who Presents With Leg Weakness, Stiffness, and Sensory Disturbances

Insulin Resistance and Body Shape Changes in HIV-Infected Patients

• Lipoatrophy Management in a Male HIV-Positive Patient
• Management of Body Composition Changes in an HIV-Positive Man With Undetectable Viral Load on HAART Therapy
• Insulin Resistance in an HIV-Infected Man: Management Perspectives

Use of Boosted Protease Inhibitor-Based Regimens in Treatment-Experienced Patients

• Use of Sequential Boosted-PI Regimens in an HIV-Infected Patient With Adherence Problems
• Balancing Efficacy and Toxicity in a Highly Treatment–Experienced Patient Receiving Boosted PIs
• Management of Adverse Events in an HIV-Infected Woman Receiving Boosted PIs

Fixed-Dose Combination NRTIs in the Treatment of HIV Infection

• Management of Adverse Effects in a Man Initiating Antiretroviral Therapy Using Fixed-Dose NRTIs
• Management of Emergent Drug Resistance Following HAART Initiation With Fixed-Dose NRTIs
• Management of Long-Term Toxicities in a Man Initiating Antiretroviral Therapy Using Fixed-Dose NRTIs

Use of Resistance Testing to Guide Therapy in HIV-Infected Patients with Multiple Regimen Failure

• Management of a Patient After First and Second Regimen Failure
• Use and Interpretation of Resistance Tests in a Highly Treatment-Experienced Patient
• Management of a Patient With NNRTI Hypersusceptibility in the Setting of High-Level NRTI and PI Resistance

Strategies for the Management of Multiclass-Resistant Patients

• Management of a Patient With Multidrug-Resistant HIV Acquired by Transmission
• Management of a Multiclass-Experienced Patient With Low-Level Viremia and Several Cardiovascular Risk Factors
• Management of a Patient With Multiple Regimen Failures and Difficult Follow-up

Managing Metabolic Issues and Cardiovascular Risk in HIV-Infected Patients

• Antiretroviral management of a treatment-naive, HIV-infected patient with significant cardiovascular risk factors
• Individualizing antiretroviral therapy in treated HIV-infected patients with dyslipidemia
• Management of an HIV-Positive Patient With Insulin Resistance While On Antiretroviral Therapy

Treatment Strategies With NNRTIs: Use in First-Line vs Later Regimens

• Management of a Patient Initiating a First-Line NNRTI-Based HAART Regimen
• Management of a Patient With Early Virologic Failure of an Initial PI-Based HAART Regimen

The Importance of Pharmacokinetic Factors in Successful Antiretroviral Therapy

• Treatment of Tuberculosis in a Patient Coinfected With HIV
• Management of an HIV-Infected Patient With Treatment-Associated Renal Abnormalities
• Management of Antiretroviral Adverse Effects in a Young HIV-Infected Woman

New and Investigational Anti-HIV Agents: Switching Strategies and Durability

• Management of a Highly Treatment-Experienced HIV-Infected Patient With Multiclass Resistance
• Management of a Young HIV-infected Woman Failing First-line Antiretroviral Therapy

Optimizing the NRTI Backbone in HIV-Infected Patients Receiving Antiretroviral Therapy

• Avoidance and Management of NRTI Toxicities
• Optimizing Antiretroviral Therapy in a Young, Newly Diagnosed, HIV-Infected Woman
• Regarding Antiretroviral Therapy for an HIV-Infected Woman Who Plans to Become Pregnant

Double-Boosted Protease Inhibitors

• A Treatment-Naive Patient Infected With Multiclass-Resistant HIV
• A Patient with a History of NRTI-Associated Lactic Acidosis
• Salvage Therapy in a Multidrug-Experienced Patient

New Agents and Treatment Strategies for Treatment-Experienced HIV Patients

• Management of a Modestly Treatment-Experienced Patient After Prolonged Treatment Interruption
• Management of a Multiclass-Experienced HIV-Infected Patient with Virologic Failure

Cardiovascular Risk Factors and Metabolic Complications in Patients Receiving HAART

• Management of Hyperlipidemia in a Patient Receiving a Triple-Class Regimen
• Management of Dyslipidemia in a Highly Experienced PI-Treated Patient
• Management of an African Man with Advanced HIV Infection and Significant Cardiovascular Risk